The Centromere is the ever-condensed region of a chromosome, which allows the connection of the sister chromatids. It also harbors a protein complex, the kinetocore, responsible for the adhesion of microtubules of mitotic fuse to the centromere during cell division.
The location of the centromere is a term of classification of the chromosome, which may be, for instance, metacentric if the centromere is located in the middle of it.
The centromere is a very important piece during the cell division because a malfunctioning centromere can lead to incorrect alignment and separation of the sister chromatids, resulting in wrong number of chromosomes in daughter cells, which lead to many genetic diseases like Klinefelter syndrome.
Biologia Aplicada 2°ano
Pl4 grupo 13
André Santos
Jorge Ribeiro
Mario Silva
Rui Oliveira
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