Satellite DNA or tandemly repeated DNA are DNA sequences
highly repetead present on heterochromatin and also found at centromeres, being
made up by short and simple sequences that form big sequence blocks. It is a
common feature of eukaryotic genomes
but is found less frequently in prokaryotes.
They are known as satellites because
DNA fragments containing tandemly repeated sequences form different bands when
genomic DNA is fractionated by density gradient centrifugation.
There are two types of satellite
DNA, known as microsatellies and minisatellites, where microsatellites clusters
are shorter than minisatellites. For example, Huntington’s disease it’s due to
the (CAG)n sequence extension caused by microsatellite CAG in the gene enconding
for the huntingtin protein.
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