Ribonucleotide
reductases (RNRs) is an enzyme that catalyze the conversion of ribonucleotides
to deoxyribonucleotides in all organisms and play an essential role in DNA
replication and repair.
The substrates for RNR are UDP, GDP, ADP and CDP. Because of their central role, they are also successful targets of several drugs used clinically in the treatment of number of malignancies. This happens because Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking of doxyribonucleotides (building blocks of DNA) .
The substrates for RNR are UDP, GDP, ADP and CDP. Because of their central role, they are also successful targets of several drugs used clinically in the treatment of number of malignancies. This happens because Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking of doxyribonucleotides (building blocks of DNA) .
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The different functions of different types of RNR and the the action local. |
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Ribonucleotide reductase action on DNA synthetis |
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