The Saccharomyces cerevisiae IX chromosome overview

Saccharomyces cerevisiae is a eukaryote which genome consists of 14 chromosomes. Chromosome IX is 439886bp in length and has 259 genes, 241 of which are open reading frames. The chromosome centromere is located between 355627 and 355744. The left arm is 355629bp in length and the right arm is 84141bp. There are 16 autonomous replication sequences (ARS), one of them is shown in the figure 1. This ARS is 170bp in length and can be found between base pairs 245756 and 245925. Some of the genes involved in replication are AIM20/YIL158W ATG32/YIL146C, BCY1/YIL033C, CAP2/YIL034C, EST3/YIL009C-A. The protein function associated to each referred gene is described in table 1.

Figure 1 - ARS923 sequence

Table 1 – Protein function of Open Reading Frames (ORF)

Gene	Protein function
AIM20/YIL158W	Unknown
ATG32/YIL146C	Mitochondrial outer membrane protein required to initiate mitophagy
BCY1/YIL033C	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA)
CAP2/YIL034C	Binds to the barber ends of actin filaments preventing further polymerization
EST3/YIL009C-A	Component of the telomerase holoenzyme involved in telomere replication

 References

Churcher, et al. (1997) Nature 387(6632 Suppl):84-87

 https://www.yeastgenome.org/

Grupo 3.2

Alexandra Ferreira A83757

Ana Carolina Castro A83463

Cláudia Rodrigues A86007

Marta Loureiro A84292

Miguel Barros A85309

Licenciatura em Bioquímica | UMinho