Chromosome I
Here we will describe Chromosome I (ChrI) of Saccharomyces cerevisiae, the smallest of sixteen chromosomes. It is constituted by a total of 230218
bp where one arm is composed by 78753 bp and the other one is 151465 bp. It is
founded by 89 ORFs plus 4 tRNA genes (93 genes total). At least 5 of them are
involved in replication: YAR007C (Subunit of heterotrimeric Replication Protein A - RPA); YAL013W
(Component of the Rpd3L histone deacetylase complex); YAL021C (Component of the
CCR4-NOT transcriptional complex); YAL015C (DNA N-glycosylase and
apurinic/apyrimidinic (AP) lyase); YAR002W (contributes directly to
nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC)
permeability barrier and is involved in gene tethering at the nuclear
periphery). There are eleven ARS in this chromosome: ARS102, ARS103 (its sequence is in Figure 1), ARS104,
ARS105, ARS106, ARS107, ARS108, ARS101, ARS110, AES11, ARS112.
Figure 1 - Nucleotide sequence of one ARS (ARS103).
Reference:
H. Bussey, et
al., 1995, PNAS USA 92:3809-13
Grupo
1.1.
Licenciatura
em Bioquímica
Universidade
do Minho
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